論文・成果

代表論文

吉村 昭彦
東京理科大学生命医科学研究所 分子病態学部門

  1. Makoto Ando; Taisuke Kondo; Wataru Tomisato; Minako Ito; Shigeyuki Shichino; Tanakorn Srirat; Setsuko Mise-Omata; Kensuke Nakagawara; Akihiko Yoshimura. Rejuvenating effector/exhausted CAR-T cells to stem cell memory-like CAR-T cells by resting them in the presence of CXCL12 and the NOTCH ligand. Cancer Res. Commun. 2021; 1 (1): 41-55. DOI: 10.1158/2767-9764.CRC-21-0034
  2. Tanakorn Srirat, Taeko Hayakawa, Setsuko Mise-Omata, Shigeyuki Shichino, Minako Ito, Akihiko Yoshimura et al. NR4a1/2 deletion promotes accumulation of TCF1+ stem-like precursors of exhausted CD8+ T cells in the tumor microenvironment. Cell Rep. 2024; 43(3): 113898. DOI: 10.1016/j.celrep.2024.113898.
  3. Kensuke Nakagawara, Makoto Ando, Tanakorn Srirat, Setsuko Mise-Omata, Taeko Hayakawa, Minako Ito, Koichi Fukunaga, Akihiko Yoshimura. NR4A ablation improves mitochondrial fitness for long persistence in human CAR-T cells against solid tumors. J Immunother Cancer. 2024; 12(8): e008665. DOI: 10.1136/jitc-2023-008665.

南野 徹
順天堂大学 大学院医学研究科 循環器内科

  1. Katsuumi G, Shimizu I, Suda M, Yoshida Y, Furihata T, Joki Y, Hsiao CL, Jiaqi L, Fujiki S, Abe M, Sugimoto M, Soga T, Minamino T. SGLT2 inhibition eliminates senescent cells and alleviates pathological aging. Nat Aging. 2024 Jul;4(7):926-938. DOI: 10.1038/s43587-024-00642-y.
  2. Yoshida Y, Shimizu I, Hsiao Y-H, Suda M, Katsuumi G, Seki M, Suzuki Y, Okuda S, Soga T, and Minamino T. Differing impact of phosphoglycerate mutase 1-deficiency on brown and white adipose tissue. iScience. 2022; 25(5): 104268. DOI: 10.1016/j.isci.2022.104268.
  3. 6. Suda M, Shimizu I, Katsuumi G, Yoshida Y, Matsumoto N, Hayashi Y, Ikegami R, Yoshida Y, Mikawa R, Katayama A, Wada J, Seki M, Suzuki Y, Iwama A, Nakagami H, Nagasawa A, Morishita R, Sugimoto M, Okuda S, Tsuchida M, Ozaki K, Nakanishi-Matsui M, Minamino T. Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice. Nat Aging. 2021; 1: 1117–1126. DOI: 10.1038/s43587-021-00151-2.

柳田 素子
京都大学大学院医学研究科 腎臓内科学

  1. Sato Y,… Yanagita M. CD153/CD30 signailing promotes age-dependent tertiary lymphoid tissue expansion and kidney injury. J Clin Invest. 132(2):e146071. (2022). DOI: 10.1172/JCI146071
  2. Yoshikawa T, …Yanagita M. Tertiary Lymphoid Tissues Are Microenvironments with Intensive Interactions between Immune Cells and Proinflammatory Parenchymal Cells in Aged Kidneys. J Am Soc Nephrol. 34(10):1687-1708. (2023). DOI: 10.1681/ASN.0000000000000202
  3. Lee YH, Sato Y,… Yanagita M. Advanced Tertiary Lymphoid Tissues in Protocol Biopsies are Associated with Progressive Graft Dysfunction in Kidney Transplant Recipients. J Am Soc Nephrol. 33(1):186-200. (2022). DOI: 10.1681/ASN.2021050715

岩間 厚志
東京大学医科学研究所 幹細胞治療研究センター 幹細胞分子医学

  1. Koide S, Oshima M, Kamiya T, Zheng Z, Liu Z, Rizq O, Nishiyama A, Murakami K, Yamada Y, Nakajima-Takagi Y, Rahmutulla B, Kaneda A, Yokoyama K, Yusa N, Imoto S, Miura F, Ito T, Tamura T, Nerlov C, Yamashita M, and Iwama A. Tracking Clusterin expression in hematopoietic stem cells reveals their heterogeneous composition across the lifespan. Blood. 2025 Mar 25:blood.2024025776. DOI: 10.1182/blood.2024025776.
  2. Kaito S, Aoyama K, Oshima M, Tsuchiya A, Miyota M, Yamashita M, Koide S, Nakajima-Takagi Y, Kozuka-Hata　H, Oyama　M, Yogo　T, Yabushita　T, Ito R, Ueno M, Hirao A, Tohyama K, Li C, Cojin Kawabata　K, Yamaguchi　K, Furukawa　Y, Kosako　H, Yoshimi　A, Goyama　S, Nannya　Y, Ogawa　S, Agger K, Helin　K, Yamazaki S, Koseki H, Doki N, Harada Y, Harada H, Nishiyama A, Nakanishi M, Iwama A. Inhibition of TOPORS ubiquitin ligase augments the efficacy of DNA hypomethylating agents through DNMT1 stabilization. Nat Commun. 15:7359, 2024. DOI: 10.1038/s41467-024-50498-4.
  3. Itokawa N, Oshima M, Koide S, Takayama N, Kuribayashi W, Nakajima-Takagi Y, Aoyama K, Yamazaki S, Yamaguchi K, Furukawa Y, Eto K, Iwama A. Epigenetic memories inscribed in chromatin accessibility in aged hematopoietic stem cells. Nat Commun. 13(1): 2691, 2022. DOI: 10.1038/s41467-022-30440-2.

平野 有沙
筑波大学 医学医療系・国際統合睡眠医科学研究機構

  1. Masuda K, Yoshimoto R, Li R, Sakurai T, Hirano A. Parameterized resetting model captures dose-dependent entrainment of the mouse circadian clock. Nat Commun. 2025, 16, 1421. DOI: 10.1038/s41467-025-56792-z.
  2. Masuda K, Sakurai T, Hirano A. A coupled model between circadian, cell-cycle, and redox rhythms reveals their regulation of oxidative stress. Sci Rep. 2024, 14, 15479. DOI: 10.1038/s41598-024-66347-9.
  3. Masuda K, Kon N, Iizuka K, Fukada Y, Sakurai T, Hirano A. Singularity response reveals entrainment properties in the mammalian circadian clock. Nat Commun. 2023, 14, 2819. DOI: 10.1038/s41467-023-38392-x.

張 明栄
国立研究開発法人 量子科学技術研究開発機構 先進核医学基盤研究部

  1. Yiding Zhang, Lin Xie, Masayuki Fujinaga, Yusuke Kurihara, Masanao Ogawa, Katsushi Kumata, Wakana Mori, Tomomi Kokufuta, Nobuki Nengaki, Hidekatsu Wakizaka, Rui Luo, Feng Wang, Kuan Hu, Ming-Rong Zhang. l-[5-11C]Glutamine PET imaging noninvasively tracks dynamic responses of glutaminolysis in non-alcoholic steatohepatitis. Acta Pharm Sin B. 2025;15(2):681-691. DOI: 10.1016/j.apsb.2024.07.023.
  2. Rui Luo, Yiding Zhang, Katsushi Kumata, Lin Xie, Yusuke Kurihara, Masanao Ogawa, Tomomi Kokufuta, Nobuki Nengaki, Feng Wang & Ming-Rong R. Zhang. The N-acetyltransferase 10 inhibitor [11C]remodelin: synthesis and preliminary positron emission tomography study in mice. EJNMMI Radiopharm Chem. 2025;10(1):6. DOI: 10.1186/s41181-025-00330-1.
  3. Lin Xie, Lulu Zhang, Kuan Hu, Masayuki Hanyu, Yiding Zhang, Masayuki Fujinaga, Katsuyuki Minegishi, Takayuki Ohkubo, Kotaro Nagatsu, Cuiping Jiang, Takashi Shimokawa, Kazuma Ashisuke, Noriyuki Okonogi, Shigeru Yamada, Feng Wang, Rui Wang, Ming-Rong Zhang. A 211At-labelled mGluR1 inhibitor induces cancer senescence to elicit long-lasting anti-tumor efficacy. Cell Rep Med. 2023;4(4):100960. DOI: 10.1016/j.xcrm.2023.100960.

杉浦 悠毅
京都大学医学研究科 附属がん免疫総合研究センター マルチオミクスプラットフォーム

  1. Lee AH, Orliaguet L, Youm YH, et al., Sugiura Y. Cysteine depletion triggers adipose tissue thermogenesis and weight-loss. Nature Metabolism. in press. DOI: 10.1038/s42255-025-01297-8
  2. Yamauchi S, Sugiura Y, Yamaguchi J, et al. Mitochondrial fatty acid oxidation drives senescence. Science Advances. 2024;10(43):eado5887. DOI:10.1126/sciadv.ado5887
  3. Maeda R, Seki N, Uwamino Y, Wakui M, Nakagama Y, Kido Y, Sasai M, Taira S, Toriu N, Yamamoto M, Matsuura Y, Uchiyama J, Yamaguchi G, Hirakawa M, Kim YG, Mishima M, Yanagita M, Suematsu M, Sugiura Y. Amino acid catabolite markers for early prognostication of pneumonia in patients with COVID-19. Nature Communications. 2023;14:849. DOI:10.1038/s41467-023-44266-z

伊藤 美菜子
九州大学 生体防御医学研究所 附属システム免疫学統合研究センター

  1. Takao T, Matsui A, Kikutake C, Kan-O K, Inoue A, Suyama M, Okamoto I, Ito M. Maternal asthma imprints fetal lung ILC2s via glucocorticoid signaling leading to worsened allergic airway inflammation in murine adult offspring. Nat Commun. 2025. 13;16(1):631. DOI: 10.1038/s41467-025-55941-8
  2. Watanabe M, Matsui A, Awata N, Nagafuchi A, Kawazoe M, Harada Y, Ito M. Differences in the characteristics and functions of brain and spinal cord regulatory T cells. J Neuroinflammation. 2024 1;21(1):146. DOI: 10.1186/s12974-024-03144-1.
  3. Kaneko R, Matsui A, Watanabe M, Harada Y, Kanamori M, Awata N, Kawazoe M, Takao T, Kobayashi Y, Kikutake C, Suyama M, Saito T, Saido TC, Ito M. Increased neutrophils in inflammatory bowel disease accelerate the accumulation of amyloid plaques in the mouse model of Alzheimer's disease. Inflamm Regen. 2023, 15;43(1):20. DOI: 10.1186/s41232-023-00257-7.