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張 明栄
国立研究開発法人量子科学技術研究開発機構

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張 明栄（国立研究開発法人量子科学技術研究開発機構）
張 明栄

1985年　中国薬科大学　卒業（医薬品合成化学）
1993年　岡山大学自然科学研究科 修了　博士（薬学）
1998年　科学技術振興事業団　博士研究員　
2000年　住重加速器サービス（株）社員　
2006年　独立行政法人放射線医学総合研究所 分子認識研究グループ 主任研究員、チームリーダー、グループリーダー
2016年　国立研究開発法人量子科学技術研究開発機構 先進核医学基盤研究部　部長

【専門領域】
放射性医薬品科学、医薬品合成化学

研究内容

PET を用いた老化細胞の定量化と加齢診断法の確立
  1. 老化を標的とする新規放射性薬剤を開発
  2. 動物を用いて、老化細胞の定量法と加齢診断法を確立
研究内容
PET を用いた老化細胞の定量化と加齢診断法の確立

論文

  1. Rong J, Yamasaki T, Li Y, Kumata K, Zhao C, Haider A, Chen J, Xiao Z, Fujinaga M, Hu K, Mori W, Zhang Y, Xie L, Zhou X, Collier TL, Zhang MR, Liang S. Radiosynthesis and Evaluation of Novel 11C-labeled Selective Orexin-2 Receptor Antagonists for Positron Emission Tomography Imaging. ACS Med Chem Lett, accepted.
  2. Zhang L, Zhang S, Wu J, Wang Y, Wu Y, Sun X, Wang X, Shen J, Xie L, Zhang Y, Zhang H, Hu K, Wang F, Wang R, Zhang MR. Linear Peptide-Based PET Tracers for Imaging PD-L1 in Tumors. Mol Pharm. 2023;20:4256-4267. doi: 10.1021/acs.molpharmaceut.3c00382.
  3. Zhang Y, Kumata K, Xie L, Kurihara Y, Ogawa M, Kokufuta T, Nengaki N, Zhang MR. The Glutaminase-1 Inhibitor [11C-carbony]BPTES: Synthesis and Positron Emission Tomography Study in Mice. Pharmaceuticals (Basel). 2023;16:963. doi: 10.3390/ph1607096.
  4. Yamasaki T, Ishii H, Hiraishi A, Kumata K, Wakizaka H, Zhang Y, Kurihara Y, Ogawa M, Nengaki N, Chen J, Li Y, Liang S, Zhang MR. Small-animal PET study for noninvasive quantification of transmembrane AMPA receptor regulatory protein γ-8 (TARP γ-8) in the brain. J Cereb Blood Flow Metab. 2023;43:893-904. doi: 10.1177/0271678X231152025.
  5. Xie L, Zhang L, Hu K, Hanyu M, Zhang Y, Fujinaga M, Minegishi K, Ohkubo T, Nagatsu K, Jiang C, Shimokawa T, Ashisuke K, Okonogi N, Yamada S, Wang F, Wang R, Zhang MR. A 211At-labelled mGluR1 inhibitor induces cancer senescence to elicit long-lasting anti-tumor efficacy. Cell Rep Med 2023;4:00960. doi: 10.1016/j.xcrm.2023.100960.
  6. Yu Q, Kumata K, Rong J, Chen Z, Yamasaki T, Chen J, Xiao Z, Ishii H, Hiraishi A, Shao T, Zhang Y, Hu K, Xie L, Fujinaga M, Zhao C, Mori W, Collier T, Haider A, Tomita S, Zhang MR, Liang S. Imaging of Transmembrane AMPA Receptor Regulatory Proteins by Positron Emission Tomography. J Med Chem. 2022;65:9144-9158. doi: 10.1021/acs.jmedchem.2c00377.
  7. Wang D, Zhou J, Fang W, Huang C, Chen Z, Fan M, Zhang MR, Xiao Z, Hu K, Luo L A multifunctional nanotheranostic agent potentiates erlotinib to EGFR wild-type non-small cell lung cancer. Bioact Mater. 2021;13:312-323. doi: 10.1016/j.bioactmat.2021.10.046.
  8. Fujinaga M, Ohkubo T, Yamasaki T, Kumata K, Nengaki N, Zhang MR. Scandium Triflate-Catalyzed N-[18F]Fluoroalkylation of Aryl- Or Heteroaryl-Amines with [18F]Epifluorohydrin under Mild Conditions. Org Lett. 2022;24:4024-4028. doi: 10.1021/acs.orglett.2c01459.
  9. Xiao Z, Wang D, Wang C, Chen Z, Huang C, Yang Y, Xie L, Zhang L, Xu L, Zhang MR, Hu K, Li Z, Luo L. PEIGel: A biocompatible and injectable scaffold with innate immune adjuvanticity for synergized local immunotherapy. Mater Today Bio. 2022;15:100297. doi: 10.1016/j.mtbio.2022.100297.
  10. Yamasaki T, Kumata K, Hiraishi A, Zhang Y, Wakizaka H, Kurihara Y, Nengaki N, Zhang MR. Synthesis of [11C]carbonyl-labeled cyclohexyl (5-(2-acetamidobenzo[d]thiazol-6-yl)-2-methylpyridin-3-yl)carbamate ([11C-carbonyl]PK68) as a potential PET tracer for receptor-interacting protein 1 kinase. EJNMMI Radiopharm Chem. 2022;7:4. doi: 10.1186/s41181-022-00156-1.
  11. Yamasaki T, Okada M, Hiraishi A, Mori W, Zhang Y, Fujinaga M, Wakizaka H, Kurihara Y, Nengaki N, Zhang MR. Upregulation of Striatal Metabotropic Glutamate Receptor Subtype 1 (mGluR1) in Rats with Excessive Glutamate Release Induced by N-Acetylcysteine. Neurotox Res. 2022;40:26-35. doi: 10.1007/s12640-021-00449-4.
  12. Hu K, Ma X, Xie L, Zhang Y, Hanyu M, Obata H, Zhang L, Nagatsu K, Suzuki H, Shi R, Wang W, Zhang MR. Development of a Stable Peptide-Based PET Tracer for Detecting CD133-Expressing Cancer Cells. ACS Omega. 2021;7:334-341. doi: 10.1021/acsomega.1c04711.
  13. Yamasaki T, Hatori A, Zhang Y, Mori W, Kurihara Y, Ogawa M, Wakizaka H, Rong J, Wang L, Liang S, Zhang MR. Neuroprotective effects of minocycline and KML29, a potent inhibitor of monoacylglycerol lipase, in an experimental stroke model: a small-animal positron emission tomography study. Theranostics. 2021;11:9492-9502. doi: 10.7150/thno.64320.
  14. Xie L, Hu K, Duo Y, Shimokawa T, Kumata K, Zhang Y, Jiang C, Zhang L, Nengaki N, Wakizaka H, Cao Y, Zhang MR. Off-tumor IDO1 target engagements determine the cancer-immune set point and predict the immunotherapeutic efficacy. J Immunother Cancer. 2021;9:e002616. doi: 10.1136/jitc-2021-002616.